在1例γ-干扰素受体1缺乏症患儿的播散性非结核性分枝杆菌感染

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在1例γ-干扰素受体1缺乏症患儿的播散性非结核性分枝杆

菌感染

Tsolia M.N.;Chapgier A.;Taprantzi P.;韩浩

【期刊名称】《世界核心医学期刊文摘：儿科学分册》 【年(卷),期】2006(0)12

【摘 要】We describe the case of a 2-year-old boy with disseminated infection by a rapidly growing,poorly pathogenic mycobacterial species that belonged to the Mycobacterium fortuitum-Mycobacterium peregrinum complex. He had a severe course characterized by a poor response to treatment and recurrent lymph node abscess formation. Sequencing of the interferon-γreceptor 1 gene (IFNγR1) revealed that he was homozygous for a novel null mutation,453delT. Patients presenting with disseminated infections by rapidly growing environmental

mycobacteria must be investigated for complete IFNγR1 deficiency. The spectrum of IFNγR1 genotypes associated with this immunological disorder is expanding. 【总页数】1页(P22-22)

【关键词】缺乏症;γ-干扰素;播散性;分枝杆菌菌种;分枝杆菌感染;无效突变;纯合型;完全性;免疫异常;致病性

【作 者】Tsolia M.N.;Chapgier A.;Taprantzi P.;韩浩


【作者单位】Second Departmentof Pediatrics,P. and A. Kyriakou Children's Hospital,Athens University School of Medicine,115 27 Athens,Greece 【正文语种】中 文 【中图分类】R725.1 【相关文献】

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