睾酮替代治疗性功能减退合并心绞痛患者可以改善缺血和提高生活质量

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睾酮替代治疗性功能减退合并心绞痛患者可以改善缺血和提高

生活质量

Malkin C.J.;Pugh P.J.;Morris P.D.;K.S. Channer;张明娟

【期刊名称】《世界核心医学期刊文摘：心脏病学分册》 【年(卷),期】2005(000)001

【摘 要】Background: Low serum testosterone is associated with several cardiovas cular r isk factors including dyslipidaemia, adverse clotting profiles, obesity, and ins ulin resistance. Testosterone has been reported to improve symptoms of angina an d delay time to ischaemic threshold in unselected men with coronary disease. Obj ective: This randomised single blind placebo controlled crossover study compar ed testosterone replacement therapy (Sustanon 100) with placebo in 10 men with isc haemic heart disease and hypogonadism. Results: Baseline total testosterone and bioavailable testosterone were respectively 4.2 (0.5) nmol/l and 1.7 (0.4) nmol/ l. After a month of testosterone, delta value analysis between testosterone and placebo phase showed that mean (SD) trough testosterone concentrations increased significantly by 4.8 (6.6) nmol/l (total testosterone) (p=0.05) and 3.8 (4.5) n mol/l (bioavailable testosterone) (p=0.025), time to 1 mm ST segment depression assessed by Bruce protocol exercise treadmill testing increased by 74 (54) secon ds (p=0.002), and mood scores assessed with validated questionnaires all improve d. Compared with placebo, testosterone therapy was also


associated with a signif icant reduction of total cholesterol and serum tumour necrosis factor αwith del ta values of -0.41 (0.54) mmol/l (p=0.04) and -1.8 (2.4) pg/ml (p=0.05) respec tively. Conclusion: Testosterone replacement therapy in hypogonadal men delays t ime to ischaemia, improves mood, and is associated with potentially beneficial r eductions of total cholesterol and serum tumour necrosis factor α. 【总页数】1页(P20-20)

【作 者】Malkin C.J.;Pugh P.J.;Morris P.D.;K.S. Channer;张明娟 【作者单位】M131;Cardiology;Royal Hallamshire Hospital;Glossop Road;Sheffield S102JF;United Kingdom;Dr. 【正文语种】中 文 【中图分类】R541.4 【相关文献】

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